Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Liraglutide-induced reduction of myocardial ischemia-reperfusion injury in rats via ERK1/2 signaling pathway

Zhao-ying Liu¹, Qing-rong Ji¹, Shun-peng Hu¹ , Dong-hao Zhou², Gui-ling Sun¹, Pin-jun Zhu¹

¹Department of Cardiology; ²Department of Endocrinology, Linyi Peopleâ€™s Hospital in Shandong Province, Linyi City, Shandong Province, 276000, China.

For correspondence:- Shun-peng Hu Email: hushunpeng309@126.com Tel:+86539807808

Received: 2 May 2017 Accepted: 28 July 2017 Published: 31 August 2017

Citation: Liu Z, Ji Q, Hu S, Zhou D, Sun G, Zhu P. Liraglutide-induced reduction of myocardial ischemia-reperfusion injury in rats via ERK1/2 signaling pathway. Trop J Pharm Res 2017; 16(8):1835-1840 doi: 10.4314/tjpr.v16i8.12

© 2017 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the protective effect of liraglutide on myocardial ischemia reperfusion (I/R) injury and its molecular mechanism.

Methods: Ischemia reperfusion model male Sprague-Dawley (SD) rats were randomly divided into negative control group, I/R group (saline), liraglutide group (liraglutide) and PD group (liraglutide + PD98059). The weight of myocardium in ischemic and infarction areas of the heart, myocardial injury biomarker, oxidative stress, as well as expressions of mRNA molecules of apoptosis were determined.

Results: The myocardial mass of ischemic and infarcted areas of the heart (relative to left ventricular mass) of I/R group were significantly higher (p F6; 0.05) than those of negative control group, but significantly lower in liraglutide group than in I/R group (p > 0.05). However, the parameters were significantly higher in PD group than in liraglutide group (p F6; 0.05). CK, CK-MB and LDH activities, as well as levels of cTnI and cTnT in I/R group were significantly higher (p F6; 0.05) than those of negative control group. However, the parameters were significantly lower (p F6; 0.05) in liraglutide group than in I/R group, but higher in PD group (p F6; 0.05) than in liraglutide group. Serum SOD, GSH-Px, CAT activities and tBcl-2 mRNA expression were significantly lower in I/R group than those of negative control group (p F6; 0.001), while those PD group were significantly lower than those of liraglutide group (p F6; 0.001).

Conclusion: Liraglutide alleviates myocardial ischemia-reperfusion injury and inhibits oxidative stress and apoptosis via ERK1/2 signaling pathway in rats, but further studies are required to ascertain the clinical efficacy and safety of the compound.

Keywords: Ischemia-reperfusion injury, Liraglutide, ERK1/2 signal pathway, Oxidative stress, Apoptosis